• We recently reported that the human

  2021-11-18

  

  We recently reported that the human-derived PancCa cell line PANC-1 and the human-derived hepatocellular HepG2 cell line express GPR55 mRNA and protein [21]. In PANC-1 and HepG2 cells, knockdown of GPR55 with specific siRNAs abrogates cellular uptake of Tocrifluor 1117, a selective GPR55 ligand [21]

• Antibiotic treatment suggests that cancer promoting bacteria

  2021-11-17

  

  Antibiotic treatment suggests that cancer-promoting bacteria arise from the quercetine of Grp109a mice. How does the lack of Gpr109a signaling lead to expansion of potentially cancer-promoting bacteria? Is this phenomenon related to improper development of intestinal Treg cells? Biome with cancer-p

• br Conflicts of interest br Introduction Antiretroviral ther

  2021-11-17

  

  Conflicts of interest Introduction Antiretroviral therapy (ART) is effective in reducing mortality (Detels et al., 1998), and preventing mother-to-child transmission (MTCT) (CDC, 1994, Connor et al., 1994) and sexual transmission of HIV (Cohen et al., 2011). However, the optimal time to start

• br The presence of an active glyoxalase pathway in

  2021-11-17

  

  The presence of an active glyoxalase pathway in an apicomplexan parasite was first reported in Plasmodium falciparum-infected erythrocytes (Vander Jagt et al., 1990). Some years later, glyoxalase I and both glyoxalase II enzymes were characterized in this parasite (Akoachere et al., 2005, Iozef et

• br Materials and methods br Results br Discussion The GO

  2021-11-17

  

  Materials and methods Results Discussion The GO system is an important mechanism for maintaining the integrity of genetic material in many eukaryotic organisms. This is demonstrated by the high conservation, across different evolutionary lineages, of the sequences of the proteins that compo

• To confirm the in vitro findings

  2021-11-17

  

  To confirm the in vitro findings, atorvastatin or pravastatin was given to C57BL6/J mice fed with high fat diet. Doses of atorvastatin were set to be 6 mg/kg and 12 mg/kg, which were within clinical therapeutic doses. The results revealed that treatment of atorvastatin but not pravastatin impaired g

• Natural products are a diverse

  2021-11-17

  

  Natural products are a diverse and interesting source for the discovery of new lead structures (Newman and Cragg, 2016). After a successful era of natural product research, many pharmaceutical companies stopped their investment in natural product-driven drug discovery in the 1990s. The reason behind

• SB273005 Methods Very briefly PLA polymeric nanoparticles as

  2021-11-17

  

  Methods Very briefly: PLA polymeric nanoparticles as well as liposomes were synthesized and loaded with three different FGFR inhibitors. The encapsulation efficiency, average size, PDI, zeta potential, stability and release kinetics were investigated. The most promising formulations were biological

• br Materials and methods This is a retrospective case contro

  2021-11-17

  

  Materials and methods This is a retrospective case-controlled study. The cases were selected based on the presence or absence of preeclampsia. Women enrolled in the study delivered singleton pregnancies at our institution from June 2003 to July 2004. Preeclampsia is defined as elevated blood pres

• Acetylation of histones by histone acetyltransferases stimul

  2021-11-17

  

  Acetylation of histones by histone acetyltransferases stimulates gene expression by relaxing Ethacrynic Acid structure, allowing access of transcription factors to DNA, whereas deacetylation of histones by histone deacetylases promotes chromatin condensation and transcriptional repression. Recent s

• Compared to the other histamine receptor subtypes the

  2021-11-17

  

  Compared to the other cotransport receptor subtypes, the H3 receptor exhibits rather complex pharmacology, being subject to extensive splicing, leading to two major (H3-445 and H3-365) and possibly more functional human receptor isoforms; for a comprehensive review please see Leurs et al. (2005) an

• br Introduction Adenosine triphosphate ATP is an organic mol

  2021-11-17

  

  Introduction Adenosine-5′-triphosphate (ATP) is an organic molecule (nucleoside triphosphate) which consists of adenine, ribose, and three phosphoric Temafloxacin hydrochloride residues. ATP serves as a temporary carrier of energy in all living cells, so it is a common substance in any organism.

• br Effect http www apexbt com media

  2021-11-17

  

  Effect of HDACi on Proteasomal Regulation of IκBα and p65 Levels At the transcriptional level, expression of CXCL8, as well as many other proinflammatory chemokines, is regulated by the transcription factor NFκB, which is constitutively activated in solid cancers, including OC, lung, and breast c

• GLP is known to be expressed in a

  2021-11-16

  

  GLP-1 is known to be expressed in a subset of taste bud cells and has been shown to co-localize with GPR120 in the circumvallate papillae [22]. Local GLP-1 regulates taste preference for sucrose [54]. Analogous to intestinal mediation of GLP-1 by GPR120, Martin et al.[22] report induction of GLP-1 s

• In addition researchers studying GPR agonists favor

  2021-11-16

  

  In addition, researchers studying GPR119 agonists favor the developing of candidate drugs that are more potent than DPP-4 inhibitors given that the latter are moderate agents in the treatment of DM. Although it Triacetyl Resveratrol synthesis is unclear why Sanofi-Aventis chose to terminate collabor

10067 records 247/672 page Previous Next First page 上5页 246247248249250 下5页 Last page