• br Deregulation of CDK Many neurotoxic or stress conditions

  2020-05-20

  

  Deregulation of CDK5 Many neurotoxic or stress conditions like ischemic ldk378 damage, oxidative stress, mitochondrial dysfunctions, excitotoxicity, Aβ exposure lead to disruption of the tight regulation of Cdk5 (De Strooper et al., 2010). Calpain-mediated cleavage of p35 to p25 is activated und

• br Results br Discussion Mucosal barriers are constitutively

  2020-05-19

  

  Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune S1RA (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s are found in lymphoid ti

• Recent studies show that the

  2020-05-18

  

  Recent studies show that the expression and function of some ion channels such as voltage-gated potassium channels, sodium channels and calcium channels are closely related to the proliferation, migration, and invasion of tumor cells [40], [41], [42]. Firstly, the expression of ion channels is chang

• It is common for plants that are

  2020-05-18

  

  It is common for plants that are deficient in P to invest in their roots in order to maximise P uptake from the soil. Here, plants grown in soil amended with OA had a higher root biomass:shoot Terbutaline Sulfate ratio compared with plants in the INORG-P treatment. Additionally, greater allocation o

• There is an opposite opinion indicating

  2020-05-18

  

  There is an opposite opinion indicating that EphB plays a role as cancer suppressor. Batlle et al. showed that loss of EphB expression represented a critical step in CRC progression, and CRCs that lacked EphB2 expression have been correlated with more advanced tumour stage, poor differentiation, and

• br Discussion Before comparing our results with structural s

  2020-05-18

  

  Discussion Before comparing our results with structural studies, we can turn to the Wiki on transition state theory (1935), which explains the reaction rates of elementary chemical reactions in terms of two parameters in one dimension. Structural studies contain information on the ground state, a

• br Conclusions br Introduction The terms endocrine active an

  2020-05-18

  

  Conclusions Introduction The terms endocrine active and endocrine disruptive have been used to describe an ever-expanding list of naturally-occurring and synthetic compounds that interact with mammalian hormonal systems, and in particular, the reproductive system. These compounds have been ass

• This study has several limitations

  2020-05-18

  

  This study has several limitations. First, despite the relatively large number of participants for a pharmacological neuroimaging study, sample sizes for examining the modulation of THC effects by COMT nearly were small. Therefore, these particular findings should be interpreted with caution and re

• Furthermore collagen could be further utilized to surface mo

  2020-05-18

  

  Furthermore, collagen could be further utilized to surface modification of biologically inert materials, such as polymer materials and metal materials, which are always hydrophobic, lacking functional groups and poor cell adhesion. Therefore, various strategies have been tested to improve the proper

• retinoic acid receptor This review aims to examine the liter

  2020-05-18

  

  This review aims to examine the literature on chloride retinoic acid receptor in the context of transplacental transport. After a short overview of the general cellular functions of Cl− channels in epithelia and the molecular classifications of these channels, it will focus on the evidence for the

• In modern science and technology many optimization problems

  2020-05-18

  

  In modern science and technology, many optimization problems need to be solved in real time, while these classical methods cannot render real-time solutions to these optimization problems, especially large-scale problems. As a new metaheuristic, particle swarm optimization (PSO) [18], [19] has prove

• Here we discuss implications of

  2020-05-16

  

  Here, we discuss implications of several major families of RING-type E3 ubiquitin ligases (MDM, Cullin, GRAIL, TRAF, TRIM) as targets in inflammation and immunity, and provide insights into potential small molecule interventions to mediate the cellular responses (summarized in Table 1). We briefly c

• SIRT is a representative member of Sirtuins which is a

  2020-05-16

  

  SIRT1 is a representative member of Sirtuins, which is a family of highly conserved NAD+-dependent class III histone deacetylases. SIRT1 deacetylates plentiful nonhistone protein substrates [Atgs, Foxo1, Foxo3, PGC-1α, NF-kB, E2F1 and p53] (Conrad et al., 2016; Gu et al., 2016; Tu et al., 2018) to p

• In most cases patients will not present immediately

  2020-05-16

  

  In most cases, patients will not present immediately after SM exposure because SM-induced clinical symptoms typically occur after a latency period of several hours [8], [9], [10]. When they do present, the detection of free, unbound alkylating agent is highly unlikely. For this reason, available rap

• Additionally we analysed the features of apomict and sexual

  2020-05-16

  

  Additionally, we analysed the features of apomict and sexual Boechera species DNMT proteins. All DNMT proteins showed highly similar theoretical pI, molecular weight and predicted sub-cellular localization (Table 2). Discussion Identification of the structure and expression levels of DNMTs durin

10065 records 542/671 page Previous Next First page 上5页 541542543544545 下5页 Last page